Light microscopy image of bio-molecular architecture built in the group of Prof. M. Norton, Marshal University, WV.
The THz signature of artificial DNA nanocrystal.
Phone: (434) 296-2400
The high spectral resolution of Vibratess Spectrometer makes it possible to observe well resolved vibrational resonance modes (or
groups of several modes at close frequences-vibrational bands) for biomolecules, as well as for cells. A unique spectral signatures
are generated from vibrational resonances of DNAs, RNAs, proteins.
Sub-THz Spectrometeris currently commercially available.
All of our customers will be provided with complete training package, as well as an initial database of sub-THz signatures
for their molecules (or cells) of interest.
Development and building narrow sub-band customized spectroscopic sensors
for detecting specific molecular or cell biomarkers is possible as well.
Below we demonstrate the examples of the services that can be provided by Vibratess to generate THz signatures database from macromolecules
of interest for customers.
For many years Vibratess has been working on developing procedures to predict sub-THz spectroscopic signatures from molecular components
of biological molecules using molecular dynamics (MD) and other software packages and available information on molecular/atomic composition
and three dimensional structures, such as protein data base (PDB) files.
THz signatures from nanogram sample of normal (green curve) and ovarian cancer (red) cells [Samples from UVA Medical School, Prof.
A. Jazaeri and Prof. C. Moskaluk, measurements at Vibratess, LLC].
1. THz Spectroscopic characterization of biological and organic materials including biological macromolecules and microorganisms
Creating experimental database for THz spectroscopic signatures from specific biological materials and objects
modeling for prediction and analysis of absorption signatures from biological molecules
Comparison of experimental and simulated spectra of protein thioredoxin from E.coli.
A big artificial DNA nanocrystal. Scale bar 100 microns.
Sizov I., Rahman M., Gelmont B., Norton M. L., and Globus T., "Sub-THz spectroscopic characterization of vibrational modes in artificially
designed DNA monocrystal", Chem. Phys., vol. 425, pp. 121–125, Nov. 2013. http://dx.doi.org/10.1016/j.chemphys.2013.08.015
Sub-THz absoprtion signature of DNA from E.coli cells [T. Globus, I. Sizov, and B. Gelmont, “Teraherz vibrational spectroscopy
of E. coli and molecular constituents: Computational modeling and experiment,” Advances in Bioscience and Biotechnology, 2013,
4, 493-503, doi:10.4236/abb.2013.43A065]